Both have the desire to take over the world and help each other out to fulfill their world domination goals with different schemes, but end up failing every time they do. The Brain is a genius and is mostly serious, but Pinky is goofy and energetic. Pinky and the Brain are two genetically-spliced lab mice that reside inside a cage in Acme Labs. To prove their mousey worth, they'll overthrow the Earth. Following the reboot, the mice received a mini-series in 2023: The Brain Teaches World Domination (a promotional tie-in with MasterClass). The segment returns in the 2020 reboot, structurally closer to the 19 shows with additional character/story developments. Their spin-off series, in turn, spun-off another series called Pinky, Elmyra and the Brain (adding Elmyra Duff) which did not fare well with the audience or crew. However, while they had their own series, they still sporadically appeared in Animaniacs. In 1995, they were later spun-off into their own series with the same title, that lasted until 1998. A running gag for this segment is where Brain asks Pinky if he is pondering what he is pondering to which Pinky usually replies with something drastically different from Brain's thoughts.

Pinky and the Brain is a recurring segment on Animaniacs focusing on Pinky and The Brain, two genetically-spliced lab mice who come up with various plans to take over the world. If you're looking for the Pinky and the Brain spin-off series, go hereįor other uses of the term Pinky and the Brain click here

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